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Fiscal Wizard · Single-issue tearsheet

UPB / Jun 20, 2026 Run #7262

UPB

Upstream Bio, Inc.

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.

Composite verdict

F 18.6 / 100
Bearish setup · Trend Following 14 drivers · 3 gates blocking
  • 52-Week Proximity
  • ADX DI Cross
  • Rate of Change
Consider long put target Δ ~0.70 · ~35 DTE Bearish setup, Grade A → ITM put target

Industry rank 293rd of 598 in Biotechnology

rescore-sweep
Technical synthesisRegime: downtrend
Bull 0%Evidence: High · 25 signals100% Bear
Momentum Bearish 0Mean-reversion Neutral 50
  • Late-stage trendTrend signals have been live for 90 bars — past the ~60-bar window; momentum edge decays and can reverse late in a move. (medium confidence)
Where value comes from

Earnings power doesn't cover the capital structure (high debt) — the EPV decomposition isn't meaningful for this name.

Fundamentals Weak

37.2 / 100

Score-bearing fundamentals shown here exclude gate-only risk checks. · 35 metrics shown.

Strongest
Weakest
EPS Growth (YoY) 100
Free Cash Flow Yield 0
Revenue Growth (YoY) 82
FCF Margin 1
Gross Margin 75
EBITDA Margin 2

Technicals Bearish

0.0 / 100

Bearish setup leads (52-Week Proximity, ADX DI Cross, Rate of Change); bulls gated by guards. · 43 signals shown.

Strongest
Weakest
52-Week Proximity 13
ADX DI Cross 17
Rate of Change 17

Risk Gates

3 blocking 6 caution

3 guards active, 15 signals gated.

Piotroski F-Score Blocking

Bottom-band Piotroski F blocks bullish signals — fundamental-quality risk.

MA Crossover Blocking

Blocks counter-regime signals only when the MA crossover agrees with the long-term regime.

Regime Filter Blocking

Blocks signals that oppose the long-term moving-average regime.

Cash Ratio Caution

Visual cash-cushion flag — does not mute signals.

Breakdown

Look under the hood

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Pick a category, above, to crack it open.

Every chip in either subscore card drills into the metrics or signals that fed it — including the formula, the threshold band, and what the current reading means for UPB.