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Fiscal Wizard · Single-issue tearsheet

APRE / Jun 21, 2026 Run #7394

APRE

Aprea Therapeutics, Inc.

Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidates are APR-1051, an orally bioavailable small-molecule inhibitor of WEE1 kinase that is in Phase 1 clinical trial for the treatment of patients with advanced solid tumors with biomarkers and ATRN-119, an ATR inhibitor, which is in Phase 1/2a clinical trial for solid tumor indications. The company is headquartered in Doylestown, Pennsylvania.

Composite verdict

F 17.0 / 100
Bearish setup · Trend Following 13 drivers · 5 gates blocking
  • Rate of Change
  • Engulfing
  • Double 7s
Consider long put target Δ ~0.70 · ~35 DTE Bearish setup, Grade A → ITM put target

Industry rank 315th of 598 in Biotechnology

rescore-sweep
Technical synthesisRegime: range
Bull 0%Evidence: High · 17 signals100% Bear
Momentum Bearish 5Mean-reversion Neutral 46

No notable composite patterns — the signals don't cluster into a named setup right now.

Where value comes fromMargin of safety +64%

Earnings power doesn't cover the capital structure (high debt) — the EPV decomposition isn't meaningful for this name.

Fundamentals Weak

34.0 / 100

Score-bearing fundamentals shown here exclude gate-only risk checks. · 35 metrics shown.

Strongest
Weakest
Margin of Safety 100
Free Cash Flow Yield 0
EPS Growth (YoY) 85
Return on Equity 25
P/B 75
Asset Turnover 25

Technicals Bearish

0.0 / 100

Bearish setup leads (Rate of Change, Engulfing, Double 7s); bulls gated by guards. · 43 signals shown.

Strongest
Weakest
Engulfing 6
Rate of Change 6
Double 7s 14

Risk Gates

5 blocking 3 caution

5 guards active, 22 signals gated.

Altman Z-Score Blocking

Bottom-band Altman Z blocks bullish signals — distress risk.

Piotroski F-Score Blocking

Bottom-band Piotroski F blocks bullish signals — fundamental-quality risk.

ADX Trend Weakness Blocking

Weak trend strength blocks trend-following signals in either direction.

MA Crossover Blocking

Blocks counter-regime signals only when the MA crossover agrees with the long-term regime.

Breakdown

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Every chip in either subscore card drills into the metrics or signals that fed it — including the formula, the threshold band, and what the current reading means for APRE.