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Fiscal Wizard · Single-issue tearsheet

FULC / Jun 22, 2026 Run #7663

FULC

Fulcrum Therapeutics, Inc.

Fulcrum Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops small molecules to improve the lives of patients with genetically defined diseases in the areas of high unmet medical need in the United States. Its clinical-stage product candidate is pociredir, a fetal hemoglobin inducer, which is in phase 1b clinical trial for the treatment of sickle cell disease and beta-thalassemia. The company also discovers programs for the treatment of diamond-blackfan anemia, Bone Marrow Failure Syndromes, novel fetal hemoglobin inducers, fibrotic disorders. It has licensce agreement with CAMP4 which includes certain small molecule compounds, composition of matter and method of use patent rights, and know-how to research, develop, manufacture, use, and commercialize. Fulcrum Therapeutics, Inc. was Incorporated in 2015 and is headquartered in Cambridge, Massachusetts.

Composite verdict

F 10.5 / 100
Bearish setup · Trend Following 13 drivers · 4 gates blocking
  • Vortex Signal
  • ADX DI Cross
  • Elder Force Index
Consider long put target Δ ~0.70 · ~35 DTE Bearish setup, Grade A → ITM put target

Industry rank 431st of 598 in Biotechnology

rescore-sweep
Technical synthesisRegime: volatile downtrend
Bull 0%Evidence: High · 20 signals100% Bear
Momentum Bearish 1Mean-reversion Neutral 50
  • Late-stage trendTrend signals have been live for 109 bars — past the ~60-bar window; momentum edge decays and can reverse late in a move. (medium confidence)
Where value comes fromMargin of safety -29%

Earnings power doesn't cover the capital structure (high debt) — the EPV decomposition isn't meaningful for this name.

Fundamentals Weak

20.8 / 100

Score-bearing fundamentals shown here exclude gate-only risk checks. · 35 metrics shown.

Strongest
Weakest
Greenblatt ROC 77
Free Cash Flow Yield 0
Return on Capital Employed 76
EPS Growth (YoY) 0
Return on Assets 75
Greenblatt EY 1

Technicals Bearish

0.1 / 100

Bearish setup leads (Vortex Signal, ADX DI Cross, Elder Force Index); bulls gated by guards. · 43 signals shown.

Strongest
Weakest
Vortex Signal 12
ADX DI Cross 17
Elder Force Index 25

Risk Gates

4 blocking 5 caution

4 guards active, 22 signals gated.

Piotroski F-Score Blocking

Bottom-band Piotroski F blocks bullish signals — fundamental-quality risk.

MA Crossover Blocking

Blocks counter-regime signals only when the MA crossover agrees with the long-term regime.

Realized Volatility Regime Blocking

High-vol regime mutes mean-reversion signals; low-vol regime mutes breakout signals.

Regime Filter Blocking

Blocks signals that oppose the long-term moving-average regime.

Breakdown

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Every chip in either subscore card drills into the metrics or signals that fed it — including the formula, the threshold band, and what the current reading means for FULC.